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Leo Szilárd also suggested the first purchase of the less peaceful Manhattan Project.In an admirably cautious manner, the purchase was not fission- or fusion-material.But a new wave of research, exemplified by a study published in Nature Genetics by a team at Cold Spring Harbor Laboratory (CSHL), is significantly improving our ability to target cancer cells by studying "the other 98%" of DNA in human chromosomes, sometimes called the genome's "dark matter." Research led by Michael Feigin, Ph.D., a postdoctoral researcher in the laboratory of CSHL Professor David Tuveson, M. D., looked closely at cells sampled from 308 people with pancreatic cancer, one of the most lethal malignancies, with a 5-year survival rate of only 8%. This enabled Feigin and colleagues including computational biologist Tyler Garvin, Ph.Now, after nearly a decade, it is compressed by Dr. Self-similar repeats in the DNA are visible in the billions of A, C, T, G-s (it is hopeless to try not to repeat sequences if you can only use 4 letters to write a very long book) ...but it was 2009 when I had proven that the hand-coded prototype that repeats follow the Zipf-Mandelbrot-Fractal-Parabolic-Distribution-Curve.

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Science enabled Leo Szilárd to patent the nuclear reactor for peaceful use.

The new data thus "adds depth to our understanding of things that go awry in these critical pathways, sometimes promoting cancer formation, other times providing cancer cells with advantages that enable them to crowd out healthy cells," comments Dr.

Tuveson, who in addition to leading a lab at CSHL is the Director of CSHL's NCI-designated Cancer Center and Director of Research for the Lustgarten Foundation, the nation's largest philanthropic funder of pancreatic cancer research.

Over the last decade, it has made good sense to study the genetic drivers of cancer by sequencing a tiny portion of the human genome called the exome -- the 2% of our three billion base pairs that "spell out" the 21,000 genes in our chromosomes.

If cancer is a disease precipitated by changes in genes, after all, we need to know lots about how and when different genes change in the many distinctive subtypes of cancer.

By this end of May something must have happened, since the 0.4 million hits in Google for FRACTAL CANCER catapulted in six months more than twenty-fold, to over 10 million hits in Google in the USA - and even to 120 million hits in Google India (since over there all ancient temples were architected with the very compressed information needed for the parsimonious algorithm of self-similar repeats).

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